CEF 3.3325.1750.gaabe4c4 - Windows 64
In my app, the scroll wheel stops working after you reload a page or navigate to the same page a few times. Started investigating and noticed that the same behavior happens in the cefclient app with the --off-screen-rendering-enabled command line switch in place. The behavior doesn't happen without the offscreen rendering flag.
To reproduce, run cefclient with the --off-screen-rendering-enabled command line parameter. Navigate to a page that has scrolling like https://news.google.com and use scroll wheel to scroll page. Hit the reload button and use scroll wheel again. After a few iterations, the page stops responding to the scroll wheel movement until you restart cefclient.